The project idea arises from a concrete need observed in many regions: the Alpine innovation ecosystem indeed hosts numerous traditional SMEs that tend to be characterised by a mindset often resistant to change. In addition to these, there are many start-ups with high innovation potential but often lacking experience and limited access to established channels. Lastly, there are various public and private actors involved in assisting businesses with a support service offering that is often fragmented, redundant, subject to territorial restrictions, and limited to specific fields. BE-READI ALPS aims to address these imbalances by first strengthening the network of business support organisations and simultaneously mobilising key stakeholders to redefine a common agenda to support the transnational development of the Alpine economic ecosystem. Since its implementation, the project’s outcomes include: (i) the BE-READI Points Toolkit, that enabled every Point to support companies using a comprehensive, modern, and transnational approach, effectively overcoming the fragmentation of the current Alpine Space innovation ecosystem; (ii) the establishment of the BE-READI Network, a collaborative framework at the regional level, comprising 25 host organisations in the Alpine Space that are dedicated to sustaining mature companies willing to develop second-life projects; (iii) a Strategic Roadmap for Alpine Space Competitiveness, containing a set of proposals for macroregional implementation based on discussions with decision makers and stakeholders during the BE-READI Open Tables.